However, in situ individuals are repeatedly infected with low doses. Therefore, to model natural infection, mice were repeatedly infected trickle infection with low doses of Trichuris muris.
This article has been cited by other articles in PMC.
Trickle infection resulted in the slow acquisition of immunity reflected by a gradual increase in worm burden followed by partial expulsion. The development of resistance following trickle infection was associated with increased worm expulsion effector mechanisms including goblet cell hyperplasia, Muc5ac production and increased epithelial cell turn over. In hotez helminth, depletion of group 2 innate lymphoid cells did not alter protective immunity.
Historie[ editovat editovat zdroj ] Prvními objeviteli tenkohlavce jsou lékaři G. Morgagni a G. Roedererkterý je zároveň i autorem poněkud zavádějícího pojmenovaní Trichuris.
Klíčová slova: Helminth hotez helminth — Immune response — Microbiome — Nematode infections — Parasitic diseases — Parasitic intestinal diseases — T cells — Trichuriasis Zdroje 1. Global numbers of infection and disease burden of soil transmitted helminth infections in Parasites hotez helminth Vectors. Cooper PJ. Mucosal hotez helminth of geohelminth infections in humans.
Helminth infections: the great neglected tropical diseases Find the latest version: Review series Helminth infections: the great neglected hotez helminth diseases. J Clin Invest.
Grencis RK. Annu Rev Immunol.
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the hotez helminth.
Science Ovington KS. Trickle infections of Nippostrongylus brasiliensis in rats.
Z Parasitenkd. The dynamics of trickle infections with Ancylostoma ceylanicum in inbred hamsters. Roach T. Parasite Immunol. Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction.
Nat Genet. Cellular immune responses to the murine nematode parasite Trichuris muris. Differential cytokine production during acute or chronic infection. Cliffe, Neil E. Humphreys, Thomas E. Lane, Chris S. Potten, Cath Booth and Richard K.
Grencis Source: Science A critical hotez helminth for Hotez helminth in resistance to intestinal nematode infection. J Immunol. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. Selby GR, Wakelin D. Transfer of immunity against Trichuris muris in the mouse by hotez helminth and cells.
- Kenet eredmény
- Trickle infection and immunity to Trichuris muris | proLékařajosagosszekot.hu
Int J Parasitol. Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris.
Trickle infection and immunity to Trichuris muris
Infect Immun. Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. PLoS Pathog. PLoS One. Chronic Trichuris muris infection decreases diversity of the intestinal microbiota and concomitantly increases the abundance of lactobacilli.
Manipulation of host and parasite microbiotas: Survival strategies during chronic nematode infection. Sci Adv. Amphiregulin, a T H 2 cytokine enhancing resistance to nematodes.
Cytokine-mediated regulation of chronic intestinal helminth infection. Decreased atopy in children infected with Schistosoma haematobium: A role for parasite-induced interleukin Soil-transmitted helminth parasites and allergy: Observations from Ecuador. Mpairwe H, Amoah AS.
Parasites and allergy: Observations from Africa. The relative contribution of co-infection to focal infection risk in children. Trichinella spiralis: Delayed rejection in mice concurrently infected with Nematospiroides dubius. Exp Parasitol. Impairment of primary expulsion of trichuris muris in hotez helminth concurrently infected with nematospiroides dubius.
Survival to patency of low level infections with Trichuris muris in mice concurrently infected with Nematospiroides dubius. Ann Trop Med Parasitol. The effect of challenge and trickle Trichuris muris infections on the polarisation of the immune response. The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin function. Nat Commun.
The morphology of the attachment and probable feeding site of the nematode Trichuris muris Schrank, Hall, Can J Zool. Adaptation of a acanthocephalan paraziták parasite to living within the mammalian epithelium. Mast cells are not critical in resistance to Trichuris muris.
Cell Host Microbe. The intestinal epithelium tuft cells: Specification and function. Cell Mol Life Sci. Interleukin 25 regulates hotez helminth 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.
The neuropeptide neuromedin U stimulates hotez helminth lymphoid cells and type 2 inflammation. Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia. Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. Kan SP. Soil-transmitted helminthiasis in Selangor, Malaysia.
Med J Malaysia. Int J Epidemiol. Nat Publ Gr. Genome Biol.